diff --git a/setup.py b/setup.py
index 92d3facf..e0037306 100755
--- a/setup.py
+++ b/setup.py
@@ -100,7 +100,6 @@
     'Programming Language :: Python :: 2',
     'Programming Language :: Python :: 2.7',
     'Programming Language :: Python :: 3',
-    'Programming Language :: Python :: 3.5',
     'Programming Language :: Python :: 3.6',
     'Programming Language :: Python :: 3.7',
     'Programming Language :: Python :: 3.8',
@@ -113,7 +112,7 @@
     'Source': 'https://github.com/theupdateframework/tuf',
     'Issues': 'https://github.com/theupdateframework/tuf/issues'
   },
-  python_requires=">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*, !=3.4.*, <4",
+  python_requires=">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*, !=3.4.*, !=3.5.*, <4",
   install_requires = [
     'requests>=2.19.1',
     'six>=1.11.0',