diff --git a/frontend/pages/admin/OrgSettingsPage/cards/Advanced/Advanced.tsx b/frontend/pages/admin/OrgSettingsPage/cards/Advanced/Advanced.tsx
index d8eacbba4a..abc98c7e95 100644
--- a/frontend/pages/admin/OrgSettingsPage/cards/Advanced/Advanced.tsx
+++ b/frontend/pages/admin/OrgSettingsPage/cards/Advanced/Advanced.tsx
@@ -446,7 +446,7 @@ const Advanced = ({
                     </>
                   )
                 }
-                helpText="Features that run scripts under-the-hood (e.g. software install, lock/wipe) will still be available."
+                helpText="Features that run scripts under-the-hood (e.g. software install, lock/wipe, payload-free packages) will still be available."
               >
                 Disable script execution features
               </Checkbox>
diff --git a/frontend/pages/hosts/details/HostDetailsPage/HostActionsDropdown/HostActionsDropdown.tests.tsx b/frontend/pages/hosts/details/HostDetailsPage/HostActionsDropdown/HostActionsDropdown.tests.tsx
index 8c447c4150..a6c044d3f9 100644
--- a/frontend/pages/hosts/details/HostDetailsPage/HostActionsDropdown/HostActionsDropdown.tests.tsx
+++ b/frontend/pages/hosts/details/HostDetailsPage/HostActionsDropdown/HostActionsDropdown.tests.tsx
@@ -1158,6 +1158,11 @@ describe("Host Actions Dropdown", () => {
           app: {
             isGlobalAdmin: true,
             currentUser: createMockUser(),
+            config: {
+              server_settings: {
+                scripts_disabled: false, // scriptsGloballyDisabled = false
+              },
+            },
           },
         },
       });
@@ -1176,16 +1181,20 @@ describe("Host Actions Dropdown", () => {
       );
 
       await user.click(screen.getByText("Actions"));
-
       expect(screen.getByText("Run script")).toBeInTheDocument();
     });
 
-    it("renders the Run script action as enabled when `scripts_enabled` is `null`", async () => {
+    it("renders the Run script action as enabled when scripts_enabled is null", async () => {
       const render = createCustomRenderer({
         context: {
           app: {
             isGlobalAdmin: true,
             currentUser: createMockUser(),
+            config: {
+              server_settings: {
+                scripts_disabled: false,
+              },
+            },
           },
         },
       });
@@ -1232,6 +1241,11 @@ describe("Host Actions Dropdown", () => {
           app: {
             isGlobalAdmin: true,
             currentUser: createMockUser(),
+            config: {
+              server_settings: {
+                scripts_disabled: false,
+              },
+            },
           },
         },
       });
@@ -1256,13 +1270,51 @@ describe("Host Actions Dropdown", () => {
           ?.parentElement
       ).toHaveClass("actions-dropdown-select__option--is-disabled");
 
+      await waitFor(() => user.hover(screen.getByText("Run script")));
+      expect(
+        screen.getByText(/fleetd agent with --enable-scripts/i)
+      ).toBeInTheDocument();
+    });
+
+    it("renders the Run script action as disabled when scripts are disabled globally", async () => {
+      const render = createCustomRenderer({
+        context: {
+          app: {
+            isGlobalAdmin: true,
+            currentUser: createMockUser(),
+            config: {
+              server_settings: {
+                scripts_disabled: true, // scriptsGloballyDisabled = true
+              },
+            },
+          },
+        },
+      });
+
+      const { user } = render(
+        <HostActionsDropdown
+          hostTeamId={null}
+          onSelect={noop}
+          hostStatus="online"
+          isConnectedToFleetMdm
+          hostPlatform="darwin"
+          hostMdmEnrollmentStatus={null}
+          hostMdmDeviceStatus="unlocked"
+          hostScriptsEnabled
+        />
+      );
+
+      await user.click(screen.getByText("Actions"));
+
       await waitFor(() => {
         waitFor(() => {
           user.hover(screen.getByText("Run script"));
         });
 
         expect(
-          screen.getByText(/fleetd agent with --enable-scripts/i)
+          screen.getByText(
+            /Running scripts is disabled in organization settings./i
+          )
         ).toBeInTheDocument();
       });
     });
diff --git a/frontend/pages/hosts/details/HostDetailsPage/HostActionsDropdown/HostActionsDropdown.tsx b/frontend/pages/hosts/details/HostDetailsPage/HostActionsDropdown/HostActionsDropdown.tsx
index 54ad92f2b3..76150a4f7f 100644
--- a/frontend/pages/hosts/details/HostDetailsPage/HostActionsDropdown/HostActionsDropdown.tsx
+++ b/frontend/pages/hosts/details/HostDetailsPage/HostActionsDropdown/HostActionsDropdown.tsx
@@ -74,6 +74,7 @@ const HostActionsDropdown = ({
     doesStoreEncryptionKey: doesStoreEncryptionKey ?? false,
     hostMdmDeviceStatus,
     hostScriptsEnabled,
+    scriptsGloballyDisabled: globalConfig?.server_settings.scripts_disabled,
     isPrimoMode: globalConfig?.partnerships?.enable_primo ?? false,
     hostMdmEnrollmentStatus,
   });
diff --git a/frontend/pages/hosts/details/HostDetailsPage/HostActionsDropdown/helpers.tsx b/frontend/pages/hosts/details/HostDetailsPage/HostActionsDropdown/helpers.tsx
index a9a4c5a5ee..e4c7db7b93 100644
--- a/frontend/pages/hosts/details/HostDetailsPage/HostActionsDropdown/helpers.tsx
+++ b/frontend/pages/hosts/details/HostDetailsPage/HostActionsDropdown/helpers.tsx
@@ -89,6 +89,7 @@ interface IHostActionConfigOptions {
   doesStoreEncryptionKey: boolean;
   hostMdmDeviceStatus: HostMdmDeviceStatusUIState;
   hostScriptsEnabled: boolean | null;
+  scriptsGloballyDisabled: boolean | undefined;
   isPrimoMode: boolean;
   hostMdmEnrollmentStatus: MdmEnrollmentStatus | null;
 }
@@ -283,6 +284,8 @@ const canRunScript = ({
   isTeamAdmin,
   isTeamMaintainer,
 }: IHostActionConfigOptions) => {
+  // Scripts globally disabled, shown as disabled by modifyOptions
+
   return (
     (isGlobalAdmin || isGlobalMaintainer || isTeamAdmin || isTeamMaintainer) &&
     isScriptSupportedPlatform(hostPlatform)
@@ -339,8 +342,13 @@ const removeUnavailableOptions = (
 // Available tooltips for disabled options
 export const getDropdownOptionTooltipContent = (
   value: string | number,
-  isHostOnline?: boolean
+  isHostOnline?: boolean,
+  scriptsGloballyDisabled?: boolean
 ) => {
+  if (value === "runScript" && scriptsGloballyDisabled) {
+    return <>Running scripts is disabled in organization settings.</>;
+  }
+
   const tooltipAction: Record<string, string> = {
     runScript: "run scripts on",
     wipe: "wipe",
@@ -384,6 +392,7 @@ const modifyOptions = (
     hostMdmDeviceStatus,
     hostScriptsEnabled,
     hostPlatform,
+    scriptsGloballyDisabled,
   }: IHostActionConfigOptions
 ) => {
   const disableOptions = (optionsToDisable: IDropdownOption[]) => {
@@ -391,7 +400,8 @@ const modifyOptions = (
       option.disabled = true;
       option.tooltipContent = getDropdownOptionTooltipContent(
         option.value,
-        isHostOnline
+        isHostOnline,
+        scriptsGloballyDisabled
       );
     });
   };
@@ -424,6 +434,13 @@ const modifyOptions = (
     );
   }
 
+  // Disable run script feature if scripts are globally disabled
+  if (scriptsGloballyDisabled) {
+    optionsToDisable = optionsToDisable.concat(
+      options.filter((option) => option.value === "runScript")
+    );
+  }
+
   // null intentionally excluded from this condition:
   // scripts_enabled === null means this agent is not an orbit agent, or this agent is version
   // <=1.23.0 which is not collecting the scripts enabled info
diff --git a/frontend/pages/hosts/details/HostDetailsPage/modals/RunScriptModal/RunScriptModal.tsx b/frontend/pages/hosts/details/HostDetailsPage/modals/RunScriptModal/RunScriptModal.tsx
index dd9604f12b..fa7943de60 100644
--- a/frontend/pages/hosts/details/HostDetailsPage/modals/RunScriptModal/RunScriptModal.tsx
+++ b/frontend/pages/hosts/details/HostDetailsPage/modals/RunScriptModal/RunScriptModal.tsx
@@ -84,6 +84,8 @@ const RunScriptModal = ({
       generateTableColumnConfigs(
         currentUser,
         hostTeamId,
+        // 4.81+ users won't reach this modal if scripts are disabled
+        // Intentionally left disabled actions in as a safeguard
         !!config?.server_settings?.scripts_disabled,
         onClickViewScript,
         onSelectAction
diff --git a/frontend/pages/hosts/details/HostDetailsPage/modals/RunScriptModal/ScriptsTableConfig.tsx b/frontend/pages/hosts/details/HostDetailsPage/modals/RunScriptModal/ScriptsTableConfig.tsx
index a20099746a..58187b3d5a 100644
--- a/frontend/pages/hosts/details/HostDetailsPage/modals/RunScriptModal/ScriptsTableConfig.tsx
+++ b/frontend/pages/hosts/details/HostDetailsPage/modals/RunScriptModal/ScriptsTableConfig.tsx
@@ -134,7 +134,7 @@ export const generateTableColumnConfigs = (
               <TooltipWrapper
                 tipContent={
                   <div>
-                    Running scripts is disabled in organization settings
+                    Running scripts is disabled in organization settings.
                   </div>
                 }
               >