diff --git a/packages/compiler/src/shadow_css.ts b/packages/compiler/src/shadow_css.ts
index fe1bb4acc61..24304a767d5 100644
--- a/packages/compiler/src/shadow_css.ts
+++ b/packages/compiler/src/shadow_css.ts
@@ -800,30 +800,67 @@ export class ShadowCss {
     const _pseudoFunctionAwareScopeSelectorPart = (selectorPart: string) => {
       let scopedPart = '';
 
-      const cssPrefixWithPseudoSelectorFunctionMatch = selectorPart.match(
-        _cssPrefixWithPseudoSelectorFunction,
-      );
-      if (cssPrefixWithPseudoSelectorFunctionMatch) {
-        const [cssPseudoSelectorFunction] = cssPrefixWithPseudoSelectorFunctionMatch;
+      // Collect all outer `:where()` and `:is()` selectors,
+      // counting parenthesis to keep nested selectors intact.
+      const pseudoSelectorParts = [];
+      let pseudoSelectorMatch: RegExpExecArray | null;
+      while (
+        (pseudoSelectorMatch = _cssPrefixWithPseudoSelectorFunction.exec(selectorPart)) !== null
+      ) {
+        let openedBrackets = 1;
+        let index = _cssPrefixWithPseudoSelectorFunction.lastIndex;
 
-        // Unwrap the pseudo selector to scope its contents.
-        // For example,
-        // - `:where(selectorToScope)` -> `selectorToScope`;
-        // - `:is(.foo, .bar)` -> `.foo, .bar`.
-        const selectorToScope = selectorPart.slice(cssPseudoSelectorFunction.length, -1);
-
-        if (selectorToScope.includes(_polyfillHostNoCombinator)) {
-          this._shouldScopeIndicator = true;
+        while (index < selectorPart.length) {
+          const currentSymbol = selectorPart[index];
+          index++;
+          if (currentSymbol === '(') {
+            openedBrackets++;
+            continue;
+          }
+          if (currentSymbol === ')') {
+            openedBrackets--;
+            if (openedBrackets === 0) {
+              break;
+            }
+            continue;
+          }
         }
 
-        const scopedInnerPart = this._scopeSelector({
-          selector: selectorToScope,
-          scopeSelector,
-          hostSelector,
-        });
+        pseudoSelectorParts.push(
+          `${pseudoSelectorMatch[0]}${selectorPart.slice(_cssPrefixWithPseudoSelectorFunction.lastIndex, index)}`,
+        );
+        _cssPrefixWithPseudoSelectorFunction.lastIndex = index;
+      }
 
-        // Put the result back into the pseudo selector function.
-        scopedPart = `${cssPseudoSelectorFunction}${scopedInnerPart})`;
+      // If selector consists of only `:where()` and `:is()` on the outer level
+      // scope those pseudo-selectors individually, otherwise scope the whole
+      // selector.
+      if (pseudoSelectorParts.join('') === selectorPart) {
+        scopedPart = pseudoSelectorParts
+          .map((selectorPart) => {
+            const [cssPseudoSelectorFunction] =
+              selectorPart.match(_cssPrefixWithPseudoSelectorFunction) ?? [];
+
+            // Unwrap the pseudo selector to scope its contents.
+            // For example,
+            // - `:where(selectorToScope)` -> `selectorToScope`;
+            // - `:is(.foo, .bar)` -> `.foo, .bar`.
+            const selectorToScope = selectorPart.slice(cssPseudoSelectorFunction?.length, -1);
+
+            if (selectorToScope.includes(_polyfillHostNoCombinator)) {
+              this._shouldScopeIndicator = true;
+            }
+
+            const scopedInnerPart = this._scopeSelector({
+              selector: selectorToScope,
+              scopeSelector,
+              hostSelector,
+            });
+
+            // Put the result back into the pseudo selector function.
+            return `${cssPseudoSelectorFunction}${scopedInnerPart})`;
+          })
+          .join('');
       } else {
         this._shouldScopeIndicator =
           this._shouldScopeIndicator || selectorPart.includes(_polyfillHostNoCombinator);
@@ -962,7 +999,7 @@ class SafeSelector {
 }
 
 const _cssScopedPseudoFunctionPrefix = '(:(where|is)\\()?';
-const _cssPrefixWithPseudoSelectorFunction = /^:(where|is)\(/i;
+const _cssPrefixWithPseudoSelectorFunction = /:(where|is)\(/gi;
 const _cssContentNextSelectorRe =
   /polyfill-next-selector[^}]*content:[\s]*?(['"])(.*?)\1[;\s]*}([^{]*?){/gim;
 const _cssContentRuleRe = /(polyfill-rule)[^}]*(content:[\s]*(['"])(.*?)\3)[;\s]*[^}]*}/gim;
diff --git a/packages/compiler/test/shadow_css/shadow_css_spec.ts b/packages/compiler/test/shadow_css/shadow_css_spec.ts
index 8eb90a4c0ef..7e869cccc67 100644
--- a/packages/compiler/test/shadow_css/shadow_css_spec.ts
+++ b/packages/compiler/test/shadow_css/shadow_css_spec.ts
@@ -93,9 +93,8 @@ describe('ShadowCss', () => {
       'div[contenta]:where(.one) {}',
     );
     expect(shim('div:where() {}', 'contenta', 'hosta')).toEqualCss('div[contenta]:where() {}');
-    // See `xit('should parse concatenated pseudo selectors'`
     expect(shim(':where(a):where(b) {}', 'contenta', 'hosta')).toEqualCss(
-      ':where(a)[contenta]:where(b) {}',
+      ':where(a[contenta]):where(b[contenta]) {}',
     );
     expect(shim('*:where(.one) {}', 'contenta', 'hosta')).toEqualCss('*[contenta]:where(.one) {}');
     expect(shim('*:where(.one) ::ng-deep .foo {}', 'contenta', 'hosta')).toEqualCss(
@@ -103,15 +102,6 @@ describe('ShadowCss', () => {
     );
   });
 
-  xit('should parse concatenated pseudo selectors', () => {
-    // Current logic leads to a result with an outer scope
-    // It could be changed, to not increase specificity
-    // Requires a more complex parsing
-    expect(shim(':where(a):where(b) {}', 'contenta', 'hosta')).toEqualCss(
-      ':where(a[contenta]):where(b[contenta]) {}',
-    );
-  });
-
   it('should handle pseudo functions correctly', () => {
     // :where()
     expect(shim(':where(.one) {}', 'contenta', 'hosta')).toEqualCss(':where(.one[contenta]) {}');
@@ -200,6 +190,18 @@ describe('ShadowCss', () => {
     ).toEqualCss(
       ':where(:where(a[contenta]:has(.foo), b[contenta]) :is(.one[contenta], .two[contenta]:where(.foo > .bar))) {}',
     );
+    expect(shim(':where(.two):first-child {}', 'contenta', 'hosta')).toEqualCss(
+      '[contenta]:where(.two):first-child {}',
+    );
+    expect(shim(':first-child:where(.two) {}', 'contenta', 'hosta')).toEqualCss(
+      '[contenta]:first-child:where(.two) {}',
+    );
+    expect(shim(':where(.two):nth-child(3) {}', 'contenta', 'hosta')).toEqualCss(
+      '[contenta]:where(.two):nth-child(3) {}',
+    );
+    expect(shim('table :where(td, th):hover { color: lime; }', 'contenta', 'hosta')).toEqualCss(
+      'table[contenta] [contenta]:where(td, th):hover { color:lime;}',
+    );
 
     // complex selectors
     expect(shim(':host:is([foo],[foo-2])>div.example-2 {}', 'contenta', 'a-host')).toEqualCss(
@@ -272,6 +274,18 @@ describe('ShadowCss', () => {
     expect(shim('.one :where(:host, .two) {}', 'contenta', 'hosta')).toEqualCss(
       '.one :where([hosta], .two[contenta]) {}',
     );
+    expect(shim(':is(.foo):is(:host):is(.two) {}', 'contenta', 'hosta')).toEqualCss(
+      ':is(.foo):is([hosta]):is(.two[contenta]) {}',
+    );
+    expect(shim(':where(.one, :host .two):first-letter {}', 'contenta', 'hosta')).toEqualCss(
+      '[contenta]:where(.one, [hosta] .two):first-letter {}',
+    );
+    expect(shim(':first-child:where(.one, :host .two) {}', 'contenta', 'hosta')).toEqualCss(
+      '[contenta]:first-child:where(.one, [hosta] .two) {}',
+    );
+    expect(
+      shim(':where(.one, :host .two):nth-child(3):is(.foo, a:where(.bar)) {}', 'contenta', 'hosta'),
+    ).toEqualCss('[contenta]:where(.one, [hosta] .two):nth-child(3):is(.foo, a:where(.bar)) {}');
   });
 
   it('should handle escaped selector with space (if followed by a hex char)', () => {